The England international aggravated a thigh strain on his return to action in Saturday's loss at Stoke and will also miss next weekend's FA Cup tie at Scunthorpe.
John Heitinga (knee) could replace him if he passes a fitness test but winger Seamus Coleman is also doubtful after a blow to the ribs. Top goalscorer Tim Cahill is on international duty with Australia at the Asian Cup.
Source: PA
Source: PA