Everton midfielder Marouane Fellaini has been ruled out for the rest of the season with an ankle injury.
Joint leading-scorer Tim Cahill could be sidelined for three weeks with a foot problem.
Newcastle
Suspended: R Taylor (three matches)
Doubtful: Ameobi (fractured cheekbone), Barton & Ireland (both thigh)
Injured: Ben Arfa (broken leg), Gosling (knee), Guthrie (hamstring), Smith (ankle)
Everton
Injured: Cahill (foot), Fellaini (ankle)
MATCH PREVIEW
How this game will end up is anyone's guess. Both sides have been painfully inconsistent this season, with Everton's FA Cup exit to Championship side Reading - after knocking holders Chelsea out in the previous round - the latest surprise.
There are still 10 games to go and we don't want the season to have a nasty end to it
Newcastle manager Alan Pardew
Everton's midweek misery was compounded by the news that Marouane Fellaini requires ankle surgery and will miss the rest of the season. With fellow midfielder Tim Cahill also injured, the Toffees are in danger of finishing in the bottom half of the table for the first time since 2006.
Newcastle's return to the top flight has provided plenty of highlights. However, despite thrashing Aston Villa (6-0), Sunderland (5-1) and West Ham (5-0) this season, they have not managed back-to-back wins at St James' Park and lie a lowly 17th in the home form table.
Perhaps their campaign is best summed up by last month's remarkable 4-4 draw with Arsenal. We saw the best and worst of Newcastle in that game, and it showed how quickly fortunes can change. Neither Newcastle nor Everton need reminding of that.
MATCH FACTS
Head-to-head
• This is the 160th time these sides have met: Newcastle lead by 63 wins to 62, with 34 draws.
• Everton have not won a league match at Newcastle since 2000 - a run of eight games.
Newcastle
• Newcastle have failed to win at home since thrashing West Ham 5-0 two months ago.
• Alan Pardew's side have lost just one of nine league games in 2011.
• Only Manchester United (39) have scored more goals at home than Newcastle (31) this season.
• Newcastle have picked up more yellow cards (59) than any other Premier League side.
Everton
• Everton have not kept a clean sheet away from home for five months - since winning 2-0 at Birmingham on 2 October.
• The Toffees are the only Premier League side yet to be awarded a penalty this season.
• Only Fulham (14) have drawn more games than Everton (12) in the Premier League.
• Leighton Baines is set to make his 150th appearance for Everton.
LEADING GOALSCORERS
Newcastle
Nolan 11 goals (11 league); Ameobi: 7 goals (4 league)
NB. Carroll scored 11 goals (11 league) for Newcastle
Everton
Cahill: 9 goals (9 league); Saha: 9 goals (6 league)
MATCH OFFICIALS
Referee: Howard Webb
Assistant referees: Patrick Keane & Andy Madley
Fourth official: Mark Haywood
LAST LEAGUE MATCH LINE-UPS
Newcastle (D1-1 v Bolton, h): Harper; Simpson, Williamson, Coloccini, Enrique, R Taylor, Tiote, Nolan, Gutierrez (S Taylor 66), Best (Kuqi 90), Lovenkrands (Ranger 67). Subs not used: Krul, Campbell, Perch, Ferguson. Sent Off: Ryan Taylor (54).
Everton (W2-0 v Sunderland, h): Howard; Neville, Jagielka, Distin, Baines, Coleman, Arteta, Fellaini (Rodwell 42), Osman, Beckford (Cahill 73), Saha (Bilyaletdinov 83). Subs not used: Mucha, Hibbert, Heitinga, Baxter.
Source: BBC Sport
Source: BBC Sport